Preimplantation Genetic Testing (PGT) in IVF Treatment

A Personalized and Reliable Approach for a Healthy Pregnancy

In vitro fertilization (IVF) is one of the most significant achievements of modern medicine. Today, thanks to advanced technologies and scientific progress, the goal is not only to achieve pregnancy but also to ensure a healthy pregnancy and a healthy baby. One of the most important methods supporting this goal is Preimplantation Genetic Testing (PGT).

PGT is an advanced diagnostic technique that allows genetic evaluation of embryos before they are transferred to the uterus. This approach helps increase pregnancy success rates while significantly reducing the risk of genetic disorders.

What Is Preimplantation Genetic Testing (PGT)?

Preimplantation Genetic Testing is a procedure in which a small number of cells are taken from embryos created through IVF and analyzed genetically. This analysis allows the detection of:

• Numerical chromosomal abnormalities

• Structural chromosomal disorders

• Certain inherited genetic diseases

By selecting genetically healthy embryos for transfer, PGT supports a safer and more controlled pregnancy process.

The Role of PGT in IVF Treatment

Genetic abnormalities in embryos are among the most common reasons for IVF failure and recurrent pregnancy loss. With PGT:

• Healthy embryo selection becomes possible

• Pregnancy success rates may increase

• The risk of miscarriage can be reduced

• Successful outcomes can be achieved with single embryo transfer

In this respect, PGT is not merely a test, but a strategic tool that guides IVF treatment planning.

Who May Benefit from PGT?

PGT is not a routine procedure for every IVF patient. However, it provides significant advantages for specific patient groups.

Advanced Maternal Age

Women aged 35 and above have a higher risk of chromosomal abnormalities in embryos. PGT helps reduce this risk.

Recurrent IVF Failure

In couples who have undergone multiple IVF cycles without success, genetic factors may play a role in implantation failure.

Recurrent Pregnancy Loss

Couples with two or more miscarriages may benefit from PGT, as chromosomal abnormalities are often a contributing factor.

Genetic Disease Carriers

If either parent is a known carrier of a genetic disorder, PGT can help assess and reduce the risk of transmission to the baby.

Male Factor-Related Genetic Risks

Severe sperm abnormalities may affect embryo genetics, making PGT a valuable option.

How Is PGT Performed?

PGT is integrated into the IVF process and follows these steps:

1. Eggs and sperm are fertilized in a laboratory setting

2. Embryos are cultured until a specific developmental stage

3. A few cells are carefully biopsied from the embryo

4. These cells undergo genetic analysis

5. Genetically healthy embryos are selected for transfer

This process is performed using advanced laboratory techniques without harming embryo development.

Does PGT Guarantee Pregnancy?

PGT significantly improves the chances of a healthy pregnancy, but it does not guarantee pregnancy. IVF success depends on multiple factors, including:

• Maternal age

• Egg and sperm quality

• Uterine health

• Overall medical condition

For this reason, PGT should always be evaluated as part of a personalized treatment plan.

Why Is Personalized Planning Essential?

Every couple’s medical history, genetic background, and reproductive goals are unique. Therefore, the decision to use PGT should be based on:

• Comprehensive medical evaluation

• Genetic counseling

• Expert physician assessment

When applied to the right patient group, PGT makes the IVF journey more predictable, safe, and reassuring.

Conclusion: A Scientific Step Toward a Healthy Future

Preimplantation Genetic Testing (PGT) is one of the most valuable supportive tools in modern IVF treatment. With accurate evaluation and individualized planning, it is possible to move forward with greater confidence toward a healthy pregnancy.

When science, experience, and personalized care come together, hope becomes stronger.